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Article

Two-Variance-Component Model Improves Genetic Prediction in Family Datasets.

American journal of human genetics - 5 Nov 2015

Tucker George, Loh Po-Ru, MacLeod Iona M, Hayes Ben J, Goddard Michael E, Berger Bonnie, Price Alkes L

Abstract excerpt

Genetic prediction based on either identity by state (IBS) sharing or pedigree information has been investigated extensively with best linear unbiased prediction (BLUP) methods. Such methods were pioneered in plant and animal-breeding literature and have since been applied to predict human traits, with the aim of eventual clinical utility. However, methods to combine IBS sharing and pedigree information for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26544803
DOI: 10.1016/j.ajhg.2015.10.002
PMCID: PMC4667134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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