On the validity of within-nuclear-family genetic association analysis in samples of extended families.

Abstract excerpt

Splitting extended families into their component nuclear families to apply a genetic association method designed for nuclear families is a widespread practice in familial genetic studies. Dependence among genotypes and phenotypes of nuclear families from the same extended family arises because of genetic linkage of the tested marker with a risk variant or because of familial specificity of genetic effects due to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bipolar Disorder
• Share to Computer Simulation
• Share to Family