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Article

RUNX1 mutation associated with clonal evolution in relapsed pediatric acute myeloid leukemia with t(16;21)(p11;q22).

International journal of hematology - 1 Feb 2014

Ismael Olfat, Shimada Akira, Elmahdi Shaimaa, Elshazley Momen, Muramatsu Hideki, Hama Asahito, Takahashi Yoshiyuki, Yamada Miho, Yamashita Yuka, Horide Keizo, Kojima Seiji

Abstract excerpt

TLS/FUS-ERG chimeric fusion transcript resulting from translocation changes involving chromosomes 16 and 21 is a rare genetic event associated with acute myeloid leukemia (AML). The distinct t(16;21) AML subtype exhibits unique clinical and morphological features and is associated with poor prognosis and a high relapse rate; however, the underlying mechanism remains to be clarified. Recently, whole-genome...

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Topics

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Share to Chromosomes, Human, Pair 16
Share to Chromosomes, Human, Pair 21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clonal Evolution

Share to Core Binding Factor Alpha 2 Subunit

Share to Oncogene Proteins, Fusion

Share to Recurrence

Share to RNA-Binding Protein FUS

Share to Translocation, Genetic

Source

Identifiers

PMID: 24374719
DOI: 10.1007/s12185-013-1495-5

Genes

RUNX1
ASXL1
CBL
ERG
FLT3
FUS
IDH1
KIT
KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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