Prevalence and clinical characterization of BRCA1 and BRCA2 mutations in Korean patients with epithelial ovarian cancer.

doi:10.1111/cas.15166

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Prevalence and clinical characterization of BRCA1 and BRCA2 mutations in Korean patients with epithelial ovarian cancer.

Cancer science - 1 Dec 2021

Paik E Sun, Heo Eun Jin, Choi Chel Hun, Kim Jae-Hoon, Kim Jae-Weon, Kim Yong-Man, Park Sang-Yoon, Lee Jeong-Won, Kim Jong-Won, Kim Byoung-Gie

Abstract excerpt

This study was performed to investigate the prevalence, clinical characteristics, and treatment response according to BRCA1 and BRCA2 (BRCA) mutations in Korean patients with epithelial ovarian cancer (EOC). Two-hundred and ninety-eight Korean women diagnosed with high-grade serous and/or endometrioid EOC from 2010 to 2015 were tested for germline and 86 specimens for somatic BRCA mutations, regardless of the...

Topics

Adult
Aged
BRCA1 Protein
BRCA2 Protein
Carcinoma, Ovarian Epithelial
Female
Germ-Line Mutation
Humans
Middle Aged
Mutation
Mutation Rate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Grading

Ovarian Neoplasms

Prevalence

Republic of Korea

Retrospective Studies

Survival Analysis

Treatment Outcome

Source

Open in PubMed Open full text

Identifiers

PMID: 34657357
DOI: 10.1111/cas.15166
PMCID: PMC8645710

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