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Article

Implementation of Next-Generation Sequencing for Hepatitis B Virus Resistance Testing and Genotyping in a Clinical Microbiology Laboratory.

Journal of clinical microbiology - 1 Jan 2016

Lowe Christopher F, Merrick Linda, Harrigan P Richard, Mazzulli Tony, Sherlock Christopher H, Ritchie Gordon

Abstract excerpt

Sanger sequencing or DNA hybridization have been the primary modalities for hepatitis B (HBV) resistance testing and genotyping; however, there are limitations, such as low sensitivity and the inability to detect novel mutations. Next-generation sequencing (NGS) for HBV can overcome these limitations, but there is limited guidance for clinical microbiology laboratories to validate this novel technology. In this...

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Identifiers

PMID: 26537448
DOI: 10.1128/JCM.02229-15
PMCID: PMC4702765

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