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Article

Key Role of the Adenylate Moiety and Integrity of the Adenylate-Binding Site for the NAD(+)/H Binding to Mitochondrial Apoptosis-Inducing Factor.

Biochemistry - 1 Dec 2015

Sorrentino Luca, Calogero Alessandra Maria, Pandini Vittorio, Vanoni Maria Antonietta, Sevrioukova Irina F, Aliverti Alessandro

Abstract excerpt

Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein with pro-life and pro-death activities, which plays critical roles in mitochondrial energy metabolism and caspase-independent apoptosis. Defects in AIF structure or expression can cause mitochondrial abnormalities leading to mitochondrial defects and neurodegeneration. The mechanism of AIF-induced apoptosis was extensively investigated, whereas the...

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PMID: 26535916
DOI: 10.1021/acs.biochem.5b00898

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