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Article

Structural insights into the coenzyme mediated monomer-dimer transition of the pro-apoptotic apoptosis inducing factor.

Biochemistry - 1 Jul 2014

Ferreira Patricia, Villanueva Raquel, Martínez-Júlvez Marta, Herguedas Beatriz, Marcuello Carlos, Fernandez-Silva Patricio, Cabon Lauriane, Hermoso Juan A, Lostao Anabel, Susin Santos A, Medina Milagros

Abstract excerpt

The apoptosis-inducing factor (AIF) is a mitochondrial-flavoprotein that, after cell death induction, is distributed to the nucleus to mediate chromatinolysis. In mitochondria, AIF is present in a monomer-dimer equilibrium that after reduction by NADH gets displaced toward the dimer. The crystal...

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Identifiers

PMID: 24914854
DOI: 10.1021/bi500343r

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24914854-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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