Article
Key Residues Regulating the Reductase Activity of the Human Mitochondrial Apoptosis Inducing Factor.
Biochemistry - 25 Aug 2015
Villanueva Raquel, Ferreira Patricia, Marcuello Carlos, Usón Alejandro, Miramar M Dolores, Peleato M Luisa, Lostao Anabel, Susin Santos A, Medina Milagros
Abstract excerpt
The human Apoptosis Inducing Factor (hAIF) is a bifunctional NAD(P)H-dependent flavoreductase involved in both mitochondrial energy metabolism and caspase-independent cell death. Even though several studies indicate that both functions are redox controlled by NADH binding, the exact role of hAIF as a reductase in healthy mitochondria remains unknown. Upon reduction by NADH, hAIF dimerizes and produces very stable...
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