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Article

Excess BMP Signaling in Heterotopic Cartilage Forming in Prg4-null TMJ Discs.

Journal of dental research - 1 Mar 2016

Bechtold T E, Saunders C, Mundy C, Um H, Decker R S, Salhab I, Kurio N, Billings P C, Pacifici M, Nah H D, Koyama E

Abstract excerpt

Heterotopic cartilage develops in certain pathologic conditions, including those affecting the human temporomandibular joint (TMJ), but the underlying molecular mechanisms remain obscure. This is in part due to the fact that a reliable animal model of such TMJ diseases is not available. Here, we show that aberrant chondrocyte differentiation and ectopic cartilage formation occur spontaneously in proteoglycan 4...

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Source

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Identifiers

PMID: 26534931
DOI: 10.1177/0022034515613508
PMCID: PMC4766954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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