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Article

Distinct functions of BMP4 and GDF5 in the regulation of chondrogenesis

4 Mar 2004

Abstract excerpt

Bone morphogenetic protein 4 (BMP4) and growth/differentiation factor 5 (GDF5) are closely related protein family members and regulate early cartilage patterning and differentiation. In this study, we compared the functional outcome of their actions systematically at various stages of chondrogenesis in mouse embryonic limb bud mesenchyme grown in micromass cultures. Overall, both growth factors enhanced cartilage...

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PMID: 15048875
DOI: 10.1002/jcb.20019

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