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Article

Ezrin-radixin-moesin-binding phosphoprotein-50 regulates EGF-induced AKT activation through interaction with EGFR and PTEN.

Oncology reports - 1 Jan 2016

Zheng Junfang, Dai Yuanping, Yang Zhiyu, Yang Longyan, Peng Zhiqiang, Meng Ran, Xiong Ying, He Junqi

Abstract excerpt

Dysregulated epidermal growth factor receptor (EGFR) signaling, especially EGFR/AKT signaling, plays important roles in tumorigenesis and progression, the study on intracellular regulation of this signaling pathway has great clinical significance. Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is an important antagonist of AKT activity. Its regulation of AKT activity can be enhanced by...

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Source

Identifiers

PMID: 26531778
DOI: 10.3892/or.2015.4375

Genes

EGFR
PTEN
EGF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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