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Article

Interactions between uncoupling protein 2 gene polymorphisms, obesity and alcohol intake on liver function: a large meta-analysed population-based study.

European journal of endocrinology - 1 Dec 2015

Vimaleswaran Karani S, Cavadino Alana, Verweij Niek, Nolte Ilja M, Mateo Leach Irene, Auvinen Juha, Veijola Juha, Elliott Paul, Penninx Brenda W, Snieder Harold, Järvelin Marjo-Riitta, van der Harst Pim, Cohen Robert D, Boucher Barbara J, Hyppönen Elina

Abstract excerpt

BACKGROUND AND OBJECTIVE: Given the role of uncoupling protein 2 (UCP2) in the accumulation of fat in the hepatocytes and in the enhancement of protective mechanisms in acute ethanol intake, we hypothesised that UCP2 polymorphisms are likely to cause liver disease through their interactions with obesity and alcohol intake. To test this hypothesis, we investigated the interaction between tagging polymorphisms in...

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Identifiers

PMID: 26526553
DOI: 10.1530/EJE-15-0839

Genes

UCP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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