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A Short BRCA2-Derived Cell-Penetrating Peptide Targets RAD51 Function and Confers Hypersensitivity toward PARP Inhibition

13 Apr 2018

Abstract excerpt

Abstract Under conditions of genotoxic stress, cancer cells strongly rely on efficient DNA repair to survive and proliferate. The human BRCA2 tumor suppressor protein is indispensable for the repair of DNA double-strand breaks by homologous recombination (HR) by virtue of its ability to promote RAD51 loading onto single-stranded DNA. Therefore, blocking the interaction between BRCA2 and RAD51 could significantly...

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Share to Advanced biosensing and bioanalysis techniques
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Share to PARP inhibition in cancer therapy

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PMID: 29654063
DOI: 10.1158/1535-7163.mct-17-1156

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