Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lipid flopping in the liver.

Biochemical Society transactions - 1 Oct 2015

Linton Kenneth J

Abstract excerpt

Bile is synthesized in the liver and is essential for the emulsification of dietary lipids and lipid-soluble vitamins. It is a complex mixture of amphiphilic bile acids (BAs; which act as detergent molecules), the membrane phospholipid phosphatidylcholine (PC), cholesterol and a variety of endogenous metabolites and waste products. Over the last 20 years, the combined effort of clinicians, geneticists,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP-Binding Cassette Transporters
Share to Bile Acids and Salts
Share to Biological Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipid Bilayers

Share to Liver Diseases

Share to Models, Biological

Share to Phospholipids

Source

Identifiers

PMID: 26517915
DOI: 10.1042/BST20150132

Genes

ABCB4
ABCB11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lipid flopping in the liver.PMID 26517915Read ↗

Canalicular ABC transporters and liver disease.Semantic proximity Read ↗

ABCB4 missense mutations D243A, K435T, G535D, I490T, R545C, and S978P significantly impair the lipid floppase and likely predispose to secondary pathologies in the human population.Semantic proximity Read ↗

Molecular mechanistic explanation for the spectrum of cholestatic disease caused by the S320F variant of ABCB4.Semantic proximity Read ↗

ATP8B1 and ATP11C: Two Lipid Flippases Important for Hepatocyte Function.Semantic proximity Read ↗

Genetic Analysis of ABCB4 Mutations and Variants Related to the Pathogenesis and Pathophysiology of Low Phospholipid-Associated Cholelithiasis.Semantic proximity Read ↗

Biosynthesis and trafficking of the bile salt export pump, BSEP: therapeutic implications of BSEP mutations.Semantic proximity Read ↗

Cholestasis.Semantic proximity Read ↗

Activity of the bile salt export pump (ABCB11) is critically dependent on canalicular membrane cholesterol content.Semantic proximity Read ↗

ABCB4: Insights from pathobiology into therapy.Semantic proximity Read ↗

Bile salt export pump (BSEP/ABCB11): trafficking and sorting disturbances.Semantic proximity Read ↗

Progressive familial intrahepatic cholestasis type 1.Semantic proximity Read ↗

Cholestasis: the ABCs of cellular mechanisms for impaired bile secretion--transporters and genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.