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Article

Canalicular ABC transporters and liver disease.

The Journal of pathology - 1 Jan 2012

Nicolaou Michael, Andress Edward J, Zolnerciks Joseph K, Dixon Peter H, Williamson Catherine, Linton Kenneth J

Abstract excerpt

Bile is a complex mixture that includes bile salts, the membrane phospholipid phosphatidylcholine (PC), cholesterol and various endobiotic and xenobiotic toxins, each of which is secreted across the canalicular membrane of the hepatocyte by different ATP-binding cassette (ABC) transporters. The bile salts are essential for the emulsification of dietary fat and lipophilic vitamins. They are synthesized from...

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Topics

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Share to ATP-Binding Cassette Transporters
Share to Bile Acids and Salts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biological Transport, Active

Share to Cholestasis, Intrahepatic

Share to Hepatocytes

Share to Intestinal Absorption

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Source

Identifiers

PMID: 21984474
DOI: 10.1002/path.3019

Genes

ABCB11
ABCB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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