Article
ATP8B1 and ATP11C: Two Lipid Flippases Important for Hepatocyte Function.
Digestive diseases (Basel, Switzerland) - 1 Jan 2015
Naik Jyoti, de Waart Dirk R, Utsunomiya Karina, Duijst Suzanne, Mok Kam Ho, Oude Elferink Ronald P J, Bosma Piter J, Paulusma Coen C
Abstract excerpt
P4 ATPases are lipid flippases and transport phospholipids from the exoplasmic to the cytosolic leaflet of biological membranes. Lipid flipping is important for the biogenesis of transport vesicles. Recently it was shown that loss of the P4 ATPases ATP8B1 and ATP11C are associated with severe Cholestatic liver disease. Mutation of ATP8B1 cause progressive familial Intrahepatic Cholestasis type 1 (PFIC1)and benign...
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