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Article

Characterizing diverse orthologues of the cystic fibrosis transmembrane conductance regulator protein for structural studies.

Biochemical Society transactions - 1 Oct 2015

Pollock Naomi L, Rimington Tracy L, Ford Robert C

Abstract excerpt

As an ion channel, the cystic fibrosis transmembrane conductance regulator (CFTR) protein occupies a unique niche within the ABC family. Orthologues of CFTR are extant throughout the animal kingdom from sharks to platypods to sheep, where the osmoregulatory function of the protein has been applied to differing lifestyles and diverse organ systems. In humans, loss-of-function mutations to CFTR cause the disease...

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Source

Identifiers

PMID: 26517900
DOI: 10.1042/BST20150081

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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