Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotype and function of CXCR5+CD45RA-CD4+ T cells were altered in HBV-related hepatocellular carcinoma and elevated serum CXCL13 predicted better prognosis.

Oncotarget - 29 Dec 2015

Duan Zhaojun, Gao Jian, Zhang Ling, Liang Hua, Huang Xiangbo, Xu Qiang, Zhang Yu, Shen Tao, Lu Fengmin

Abstract excerpt

The present study reveals an immunological characterization of circulating and tumor-infiltrating T follicular helper cells (Tfh), namely CXCR5+CD45RA-CD4+ T cells, and their related cytokines in hepatitis B virus-related hepatocellular carcinoma (HCC) patients. In HCC patients, circulating Tfh cells showed a CCR7+ and/or ICOS+ phenotype with increased Th2-like cells and decreased Th1-like and Th17-like subsets....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4 Lymphocyte Count
Share to Hepatectomy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B

Share to Immunophenotyping

Share to Leukocyte Common Antigens

Share to Lymphocytes, Tumor-Infiltrating

Share to Neoplasm Recurrence, Local

Share to T-Lymphocytes, Helper-Inducer

Source

Open in PubMed Open full text

Identifiers

PMID: 26517519
DOI: 10.18632/oncotarget.6235
PMCID: PMC4792554

Genes

CXCL13
CXCR5
CCR7
ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotype and function of CXCR5+CD45RA-CD4+ T cells were altered in HBV-related hepatocellular carcinoma and elevated serum CXCL13 predicted better prognosis.PMID 26517519Read ↗

Programmed death 1 expressing CD8+CXCR5+ follicular T cells constitute effector rather than exhaustive phenotype in patients with chronic hepatitis BSemantic proximity Read ↗

The role of CCR5/CXCR3 expressing CD8+ cells in liver damage and viral control during persistent hepatitis C virus infection.Semantic proximity Read ↗

CD4+CXCR5+ T cells activate CD27+IgG+ B cells via IL-21 in patients with hepatitis C virus infection.Semantic proximity Read ↗

Chemokine CCL5 immune subtypes of human liver cancer with prognostic significanceSemantic proximity Read ↗

CXCL9 and CXCL13 as Predictive Biomarkers for Autoimmune-like Phenotype in Chronic Hepatitis C: Evidence for Viral-Induced Autoimmune Hepatitis TransitionSemantic proximity Read ↗

Viral and host inflammation-related factors that can predict the prognosis of hepatocellular carcinoma.Semantic proximity Read ↗

CTLA4 + CD4 + CXCR5 - FOXP3 + T cells associate with unfavorable outcome in patients with chronic HBV infectionSemantic proximity Read ↗

IFNγ−IL-17+ CD8 T cells contribute to immunosuppression and tumor progression in human hepatocellular carcinomaSemantic proximity Read ↗

The characteristic expression of B7-H3 and B7-H4 in liver biopsies from patients with HBV-related acute-on-chronic liver failure.Semantic proximity Read ↗

CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver.Semantic proximity Read ↗

Patients with chronic hepatitis C express a high percentage of CD4(+)CXCR5(+) T follicular helper cells.Semantic proximity Read ↗

CCR5 plays important roles in hepatitis B infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.