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IFNγ−IL-17+ CD8 T cells contribute to immunosuppression and tumor progression in human hepatocellular carcinoma

21 Oct 2022

Abstract excerpt

IL-17-producing CD8 (Tc17) T cells have been shown to play an important role in infection and chronic inflammation, however their implications in hepatocellular carcinoma (HCC) remain elusive. In this study, we performed cytometry by time-of-flight (CyTOF) and revealed the distinctive immunological phenotypes of two IFNγ+ and IFNγ− Tc17 subsets that were preferentially enriched in human HCC. Single-cell...

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PMID: 36279983
DOI: 10.1016/j.canlet.2022.215977

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