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Article

The role of CCR5/CXCR3 expressing CD8+ cells in liver damage and viral control during persistent hepatitis C virus infection.

Journal of hepatology - 1 Nov 2007

Larrubia Juan-Ramón, Calvino Miryam, Benito Selma, Sanz-de-Villalobos Eduardo, Perna Cristian, Pérez-Hornedo Jaime, González-Mateos Fernando, García-Garzón Silvia, Bienvenido Antonio, Parra Trinidad

Abstract excerpt

BACKGROUND/AIMS: CXCR3 and CCR5 play a major role in recruiting cytotoxic T cells (Tc) and secreting secondary type 1 cytokines (Tc1) in the liver. HCV could impair their expression as a survival mechanism. The role of these chemokine receptors on CD8+ cells in chronic hepatitis C is analysed. METHODS: Serum, chemokines, peripheral blood and intrahepatic lymphocytes from chronic hepatitis C patients were studied....

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Topics

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Share to CD8-Positive T-Lymphocytes
Share to Cell Death

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemokine CCL3

Share to Chemokine CXCL10

Share to Interferon-alpha

Share to Receptors, CCR5

Share to Receptors, CXCR3

Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 17560677
DOI: 10.1016/j.jhep.2007.04.009

Genes

CXCR3
CCR5
CCL3
CXCL10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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