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Article

CD4+CXCR5+ T cells activate CD27+IgG+ B cells via IL-21 in patients with hepatitis C virus infection.

Hepatobiliary & pancreatic diseases international : HBPD INT - 1 Feb 2016

Kong Fan-Yun, Feng Bo, Zhang Heng-Hui, Rao Hui-Ying, Wang Jiang-Hua, Cong Xu, Wei Lai

Abstract excerpt

BACKGROUND: Chronic hepatitis C virus (HCV) infection causes the skewing and activation of B cell subsets, but the characteristics of IgG+ B cells in patients with chronic hepatitis C (CHC) infection have not been thoroughly elucidated. CD4+CXCR5+ follicular helper T (Tfh) cells, via interleukin (IL)-21 secretion, activate B cells. However, the role of CD4+CXCR5+ T cells in the activation of IgG+ B cells in CHC...

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Identifiers

PMID: 26818544
DOI: 10.1016/s1499-3872(16)60054-1

Genes

CXCR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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