Article
δ-Opioid Receptor Activation Attenuates the Oligomer Formation Induced by Hypoxia and/or α-Synuclein Overexpression/Mutation Through Dual Signaling Pathways.
Molecular neurobiology - 1 May 2019
Chen Tao, Wang Qinyu, Chao Dongman, Xia Terry C, Sheng Shiying, Li Zhuo-Ri, Zhao Jian-Nong, Wen Guo-Qiang, Ding Guanghong, Xia Ying
Abstract excerpt
We have recently demonstrated that δ-opioid receptor (DOR) activation attenuates α-synuclein expression/aggregation induced by MPP(+) and/or severe hypoxia. Since α-synuclein plays a critical role in the pathogenesis of Parkinson's disease, DOR activation may trigger an antiparkinson pathway(s) against α-synuclein-induced injury. However, the underlying mechanism is unknown yet. In HEK293T and PC12 cells, we...
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