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Article

Neuropathology of Amyotrophic Lateral Sclerosis and Its Variants.

Neurologic clinics - 1 Nov 2015

Saberi Shahram, Stauffer Jennifer E, Schulte Derek J, Ravits John

Abstract excerpt

The neuropathologic molecular signature common to almost all sporadic amyotrophic lateral sclerosis (ALS) and most familial ALS is TDP-43 immunoreactive neuronal cytoplasmic inclusions. The neuropathologic and molecular neuropathologic features of ALS variants, primarily lateral sclerosis and progressive muscular atrophy, are less certain but also seem to share the primary features of ALS. Genetic causes,...

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Identifiers

PMID: 26515626
DOI: 10.1016/j.ncl.2015.07.012
PMCID: PMC4628785

Genes

FUS
SOD1

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