Article
The genetics and neuropathology of amyotrophic lateral sclerosis.
Acta neuropathologica - 1 Sept 2012
Al-Chalabi Ammar, Jones Ashley, Troakes Claire, King Andrew, Al-Sarraj Safa, van den Berg Leonard H
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of motor neurons leading to death from respiratory failure within about 3 years of symptom onset. A family history of ALS is obtained in about 5 % but the distinction between familial and apparently sporadic ALS is artificial and genetic factors play a role in all types. For several years, only one gene was known to have a role in ALS...
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