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Article

In Vitro Mutational Analysis of the β2 Adrenergic Receptor, an In Vivo Surrogate Odorant Receptor.

PloS one - 1 Jan 2015

Jamet Sophie, Bubnell Jaclyn, Pfister Patrick, Tomoiaga Delia, Rogers Matthew E, Feinstein Paul

Abstract excerpt

Many G-protein coupled receptors (GPCRs), such as odorant receptors (ORs), cannot be characterized in heterologous cells because of their difficulty in trafficking to the plasma membrane. In contrast, a surrogate OR, the GPCR mouse β2-adrenergic-receptor (mβ2AR), robustly traffics to the plasma membrane. We set out to characterize mβ2AR mutants in vitro for their eventual use in olfactory axon guidance studies....

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Identifiers

PMID: 26513247
DOI: 10.1371/journal.pone.0141696
PMCID: PMC4626089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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