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Interplay between cadherins and α2β1 integrin differentially regulates melanoma cell invasion

29 Oct 2015

Abstract excerpt

BACKGROUND: Malignant transformation of melanocytes frequently coincides with an alteration in the expression of cell-cell adhesion molecules (cadherins) and cell-extracellular matrix proteins (integrins). How these two adhesion systems interplay to impact on cell invasion remains to be described in melanoma. METHODS: Cell adhesion networks were localised by immunofluorescence in human primary cutaneous melanoma,...

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PMID: 26512877
DOI: 10.1038/bjc.2015.358

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