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Article

Crohn's disease-derived monocytes fail to induce Paneth cell defensins

28 Oct 2015

Abstract excerpt

Crohn's disease (CD) is associated with a multitude of genetic defects, many of which likely affect Paneth cell function. Paneth cells reside in the small intestine and produce antimicrobial peptides essential for the host barrier, principally human α-defensin 5 (HD5) and HD6. Patients with CD of the ileum are characterized by reduced constitutive expression of these peptides and, accordingly, compromised...

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PMID: 26512113
DOI: 10.1073/pnas.1510084112

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