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Article

Severity of Mitral Valve Degeneration Is Associated with Chromosome 15 Loci in Whippet Dogs.

PloS one - 1 Jan 2015

Stern Joshua A, Hsue Weihow, Song Kun-Ho, Ontiveros Eric S, Luis Fuentes Virginia, Stepien Rebecca L

Abstract excerpt

Mitral valve degeneration (MVD) is the most common form of heart disease in dogs, frequently leading to left-sided congestive heart failure and cardiac mortality. Although breed-specific disease characteristics and overrepresentation point towards a genetic origin for MVD, a causative mutation and complete molecular pathogenesis are unknown. Whippet dogs are overrepresented in incidence of MVD, suggesting an...

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Source

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Identifiers

PMID: 26509595
DOI: 10.1371/journal.pone.0141234
PMCID: PMC4624976

Genes

MVD
ARHGAP26
FSTL5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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