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Article

A Combination of Alleles in LMOD2 and a lncRNA is Strongly Associated With Myxomatous Mitral Valve Disease in Cavalier King Charles Spaniels.

Animal genetics - 1 Oct 2026

Olsen Lisbeth Høier, Gunnlaugsdóttir Arney Eva, Madsen Majbritt Busk, Larsen Isabella Jane, Reimann Maria Josefine Ubbe, Papadaki Foteini, Ljungvall Ingrid, Häggström Jens, Martinussen Torben, Pedersen Henrik Duelund, Falk Torkel, Fredholm Merete, Karlskov-Mortensen Peter

Abstract excerpt

A previous genome-wide association study identified regions on canine chromosome (cfa) 13 and 14 associated with early onset myxomatous mitral valve disease (MMVD) in Cavalier King Charles Spaniels (CKCS). In the present study, whole genome sequencing (WGS) of 9 CKCS cases (mitral regurgitation (MR) before 4.5 years or congestive heart failure (CHF) at any age due to MMVD) and 10 CKCS controls (no or mild MR...

Read the complete abstract on PubMed

Topics

Animals
RNA, Long Noncoding
Dog Diseases
Dogs
Mitral Valve Prolapse

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Alleles

Mitral Valve Insufficiency

Female

Male

Genetic Predisposition to Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 42708524
DOI: 10.1002/age.70200
PMCID: PMC13552192

Genes

LMOD2
HYAL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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