Article
Genome-wide analysis of mitral valve disease in Cavalier King Charles Spaniels.
Veterinary journal (London, England : 1997) - 1 Jul 2012
French Anne T, Ogden Rob, Eland Cathlene, Hemani Gibran, Pong-Wong Ricardo, Corcoran Brendan, Summers Kim M
Abstract excerpt
The Cavalier King Charles Spaniel (CKCS) is prone to severe early onset mitral valve disease. In this study, 36 purebred CKCS dogs were evaluated for mitral valve murmur and divided into early and late onset groups. A genome-wide genetic approach was used to assess whether the condition is determined by a small number of genetic factors. There were no regions of highly discrepant homo/heterozygosity in the two...
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