Improving protein-protein interaction prediction using evolutionary information from low-quality MSAs.

Abstract excerpt

Evolutionary information stored in multiple sequence alignments (MSAs) has been used to identify the interaction interface of protein complexes, by measuring either co-conservation or co-mutation of amino acid residues across the interface. Recently, maximum entropy related correlated mutation measures (CMMs) such as direct information, decoupling direct from indirect interactions, have been developed to identify...

Topics

• Algorithms
• Amino Acid Sequence
• Computational Biology
• Datasets as Topic
• Evolution, Molecular
• Models, Molecular
• Mutation
• Protein Binding
• Protein Conformation
• Protein Interaction Mapping
• Proteins