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Article

PAR-1 and thrombin: the ties that bind the microenvironment to melanoma metastasis.

Cancer research - 1 Nov 2011

Zigler Maya, Kamiya Takafumi, Brantley Emily C, Villares Gabriel J, Bar-Eli Menashe

Abstract excerpt

Progression of melanoma is dependent on cross-talk between tumor cells and the adjacent microenvironment. The thrombin receptor, protease-activated receptor-1 (PAR-1), plays a key role in exerting this function during melanoma progression. PAR-1 and its activating factors, which are expressed on tumor cells and the surrounding stroma, induce not only coagulation but also cell signaling, which promotes the...

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Share to Blood Coagulation
Share to Endothelial Cells
Share to Melanoma, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplastic Cells, Circulating

Share to Receptor, PAR-1

Share to Stromal Cells

Share to Thrombin

Share to Xenograft Model Antitumor Assays

Source

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Identifiers

PMID: 22009534
DOI: 10.1158/0008-5472.CAN-11-1432
PMCID: PMC3206157

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