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Article

The 5'-untranslated region of p16INK4a melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 binding.

Oncotarget - 24 Nov 2015

Bisio Alessandra, Latorre Elisa, Andreotti Virginia, Bressac-de Paillerets Brigitte, Harland Mark, Scarra Giovanna Bianchi, Ghiorzo Paola, Spitale Robert C, Provenzani Alessandro, Inga Alberto

Abstract excerpt

CDKN2A/p16INK4a is an essential tumor suppressor gene that controls cell cycle progression and replicative senescence. It is also the main melanoma susceptibility gene. Here we report that p16INK4a 5'UTR mRNA acts as a cellular Internal Ribosome Entry Site (IRES). The potential for p16INK4a 5'UTR to drive cap-independent translation was evaluated by dual-luciferase assays using bicistronic and monocistronic...

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Identifiers

PMID: 26498684
DOI: 10.18632/oncotarget.5387
PMCID: PMC4741874

Genes

YBX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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