Article
Association between brain-muscle-ARNT-like protein-2 (BMAL2) gene polymorphism and type 2 diabetes mellitus in obese Japanese individuals: A cross-sectional analysis of the Japan Multi-institutional Collaborative Cohort Study.
Diabetes research and clinical practice - 1 Dec 2015
Yamaguchi Miwa, Uemura Hirokazu, Arisawa Kokichi, Katsuura-Kamano Sakurako, Hamajima Nobuyuki, Hishida Asahi, Suma Shino, Oze Isao, Nakamura Kazuyo, Takashima Naoyuki, Suzuki Sadao, Ibusuki Rie, Mikami Haruo, Ohnaka Keizo, Kuriyama Nagato, Kubo Michiaki, Tanaka Hideo
Abstract excerpt
AIMS: Brain-muscle-Arnt-like protein-1 (BMAL1) and BMAL2 genes are essential components of the circadian clock, and are considered to be involved in glucose homeostasis. We examined whether single nucleotide polymorphisms (SNPs) of BMAL1 and BMAL2 were associated with the prevalence of type 2 diabetes (T2DM) in the general Japanese population. METHODS: We studied 2467 subjects (1232 men and 1235 women, 35-69...
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