Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

POLE somatic mutations in advanced colorectal cancer.

Cancer medicine - 1 Dec 2017

Guerra Joana, Pinto Carla, Pinto Diana, Pinheiro Manuela, Silva Romina, Peixoto Ana, Rocha Patrícia, Veiga Isabel, Santos Catarina, Santos Rui, Cabreira Verónica, Lopes Paula, Henrique Rui, Teixeira Manuel R

Abstract excerpt

Despite all the knowledge already gathered, the picture of somatic genetic changes in colorectal tumorigenesis is far from complete. Recently, germline and somatic mutations in the exonuclease domain of polymerase epsilon, catalytic subunit (POLE) gene have been reported in a small subset of microsatellite-stable and hypermutated colorectal carcinomas (CRCs), affecting the proofreading activity of the enzyme and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

Share to Colorectal Neoplasms

Share to DNA Polymerase II

Share to Microsatellite Instability

Share to Poly-ADP-Ribose Binding Proteins

Share to Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed Open full text

Identifiers

PMID: 29072370
DOI: 10.1002/cam4.1245
PMCID: PMC5727326

Genes

POLE
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

POLE somatic mutations in advanced colorectal cancer.PMID 29072370Read ↗

Polymerase epsilon mutations and concomitant β2-microglobulin mutations in cancer.Semantic proximity Read ↗

A mutation in POLE predisposing to a multi-tumour phenotype.Semantic proximity Read ↗

Mutations in POLE and survival of colorectal cancer patients--link to disease stage and treatment.Semantic proximity Read ↗

A novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestine.Semantic proximity Read ↗

Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancerSemantic proximity Read ↗

Clinicopathological and mutational analyses of colorectal cancer with mutations in the POLE geneSemantic proximity Read ↗

Exploring somatic mutations in POLE and POLD1: Their role in colorectal cancer pathogenesis and potential therapeutic strategiesSemantic proximity Read ↗

Genetic, structural, and functional characterization of POLE polymerase proofreading variants allows cancer risk prediction.Semantic proximity Read ↗

Comprehensive Analysis of Human Colorectal Cancers Harboring Polymerase Epsilon Mutations.Semantic proximity Read ↗

DNA polymerase epsilon catalytic subunit (POLE) in cancer: Implications for tumor biology and therapeutic strategies - A comprehensive review.Semantic proximity Read ↗

Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer.Semantic proximity Read ↗

Exploring the basis of heterogeneity of cancer aggressiveness among the mutated POLE variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.