Article
A novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestine.
Familial cancer - 1 Sept 2015
Hansen Maren F, Johansen Jostein, Bjørnevoll Inga, Sylvander Anna E, Steinsbekk Kristin S, Sætrom Pål, Sandvik Arne K, Drabløs Finn, Sjursen Wenche
Abstract excerpt
In some families there is an increased risk for colorectal cancer, caused by heritable, but often unidentified genetic mutations predisposing to the disease. We have identified the likely genetic cause for disease predisposition in a large family with high burden of colorectal adenomas and carcinomas, in addition to extra-colonic cancers. This family had previously been tested for known cancer susceptibility...
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