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Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development

25 Feb 2015

Abstract excerpt

Heritable genetic variants can significantly affect the lifetime risk of developing cancer, including polyposis and colorectal cancer (CRC). Variants in genes currently known to be associated with a high risk for polyposis or CRC, however, explain only a limited number of hereditary cases. The identification of additional genetic causes is, therefore, crucial to improve CRC prevention, detection and treatment. We...

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PMID: 25712196
DOI: 10.1002/path.4520

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