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Article

A stem cell marker-expressing subset of enteroendocrine cells resides at the crypt base in the small intestine.

American journal of physiology. Gastrointestinal and liver physiology - 1 Feb 2011

Sei Yoshitatsu, Lu Xinping, Liou Alice, Zhao Xilin, Wank Stephen A

Abstract excerpt

The spatial orientation of the enteroendocrine cells along the crypt-villus axis is closely associated with their differentiation in the intestine. Here we studied this relationship using primary duodenal crypts and an ex vivo organoid system established from cholecystokinin-green fluorescent protein (CCK-GFP) transgenic mice. In the primary duodenal crypts, GFP+ cells were found not only in the upper crypt but...

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Identifiers

PMID: 21088235
DOI: 10.1152/ajpgi.00278.2010
PMCID: PMC3043655

Genes

CCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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