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Article

Pur-alpha functionally interacts with FUS carrying ALS-associated mutations.

Cell death & disease - 22 Oct 2015

Di Salvio M, Piccinni V, Gerbino V, Mantoni F, Camerini S, Lenzi J, Rosa A, Chellini L, Loreni F, Carrì M T, Bozzoni I, Cozzolino M, Cestra G

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder due to motor neuron loss. Fused in sarcoma (FUS) protein carrying ALS-associated mutations localizes to stress granules and causes their coalescence into larger aggregates. Here we show that Pur-alpha physically interacts with mutated FUS in an RNA-dependent manner. Pur-alpha colocalizes with FUS carrying mutations in stress granules of...

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Source

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Identifiers

PMID: 26492376
DOI: 10.1038/cddis.2015.295
PMCID: PMC4632316

Genes

FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Pur-alpha functionally interacts with FUS carrying ALS-associated mutations.PMID 26492376Read ↗

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