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Article

MET18 Connects the Cytosolic Iron-Sulfur Cluster Assembly Pathway to Active DNA Demethylation in Arabidopsis.

PLoS genetics - 1 Oct 2015

Duan Cheng-Guo, Wang Xingang, Tang Kai, Zhang Huiming, Mangrauthia Satendra K, Lei Mingguang, Hsu Chuan-Chih, Hou Yueh-Ju, Wang Chunguo, Li Yan, Tao W Andy, Zhu Jian-Kang

Abstract excerpt

DNA demethylation mediated by the DNA glycosylase ROS1 helps determine genomic DNA methylation patterns and protects active genes from being silenced. However, little is known about the mechanism of regulation of ROS1 enzymatic activity. Using a forward genetic screen, we identified an anti-silencing (ASI) factor, ASI3, the dysfunction of which causes transgene promoter hyper-methylation and silencing. Map-based...

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Identifiers

PMID: 26492035
DOI: 10.1371/journal.pgen.1005559
PMCID: PMC4619598

Genes

ROS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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