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Nuclear factor B as a target for new drug development in myeloid malignancies

1 Sept 2007

Abstract excerpt

The transcription nuclear factor k B (NF-kB) can intervene in oncogenesis through to its capacity to regulate the expression of a large number of genes that regulate apoptosis, cell proliferation and differentiation as well as inflammation, angiogenesis and tumor migration. Impaired NF-kB activity has been demonstrated not only in solid cancers but also in various types of hematologic malignancies including acute...

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PMID: 17666366
DOI: 10.3324/haematol.11199

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