Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational robustness and resilience of a replicative cis-element of RNA virus: Promiscuity, limitations, relevance.

RNA biology - 1 Jan 2015

Prostova Maria A, Gmyl Anatoly P, Bakhmutov Denis V, Shishova Anna A, Khitrina Elena V, Kolesnikova Marina S, Serebryakova Marina V, Isaeva Olga V, Agol Vadim I

Abstract excerpt

Since replication of RNA-viruses is generally a low-fidelity process, it would be advantageous, if specific interactions of their genomic cis-elements with dedicated ligands are relatively tolerant to mutations. The specificity/promiscuity trade-off of such interactions was addressed here by investigating structural requirements of the oriL (also known as the clover leaf-like element), of poliovirus RNA, a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Pairing
Share to Genetic Engineering

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Viral

Share to Nucleotides

Share to Regulatory Sequences, Nucleic Acid

Share to RNA, Viral

Share to RNA Viruses

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 26488412
DOI: 10.1080/15476286.2015.1100794
PMCID: PMC4829312

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational robustness and resilience of a replicative cis-element of RNA virus: Promiscuity, limitations, relevance.PMID 26488412Read ↗

Emergency Services of Viral RNAs: Repair and Remodeling.Semantic proximity Read ↗

Error thresholds and the constraints to RNA virus evolution.Semantic proximity Read ↗

Mechanisms of genetic robustness in RNA viruses.Semantic proximity Read ↗

Cis-element, oriR, involved in the initiation of (-) strand poliovirus RNA: a quasi-globular multi-domain RNA structure maintained by tertiary ('kissing') interactions.Semantic proximity Read ↗

Multiple levels of triggered factors and positive effect of cell-to-cell bottleneck in mutation repair of RNA virusesSemantic proximity Read ↗

A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape.Semantic proximity Read ↗

Genome replication of Newcastle disease virus: involvement of the rule-of-sixSemantic proximity Read ↗

Genetic stability and instability of the cis-acting control element of the 5' untranslated region of the poliovirus RNA.Semantic proximity Read ↗

Structural and Functional Basis of the Fidelity of Nucleotide Selection by Flavivirus RNA-Dependent RNA PolymerasesSemantic proximity Read ↗

Comparison of CpG- and UpA-mediated restriction of RNA virus replication in mammalian and avian cells and investigation of potential ZAP-mediated shaping of host transcriptome compositionsSemantic proximity Read ↗

Viral protein instability enhances host-range evolvability.Semantic proximity Read ↗

Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside AnaloguesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.