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Article

Normal Fertility Requires the Expression of Carbonic Anhydrases II and IV in Sperm.

The Journal of biological chemistry - 4 Dec 2015

Wandernoth Petra M, Mannowetz Nadja, Szczyrba Jaroslaw, Grannemann Laura, Wolf Anne, Becker Holger M, Sly William S, Wennemuth Gunther

Abstract excerpt

HCO3 (-) is a key factor in the regulation of sperm motility. High concentrations of HCO3 (-) in the female genital tract induce an increase in sperm beat frequency, which speeds progress of the sperm through the female reproductive tract. Carbonic anhydrases (CA), which catalyze the reversible hydration of CO2 to HCO3 (-), represent potential candidates in the regulation of the HCO3 (-) homeostasis in sperm and...

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Identifiers

PMID: 26487715
DOI: 10.1074/jbc.M115.698597
PMCID: PMC4705926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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