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Article

Conserved Mechanism of Bicarbonate-Induced Sensitization of CatSper Channels in Human and Mouse Sperm

28 Sept 2021

Abstract excerpt

To fertilize an egg, mammalian sperm must undergo capacitation in the female genital tract. A key contributor to capacitation is the calcium (Ca2+) channel CatSper, which is activated by membrane depolarization and intracellular alkalinization. In mouse epididymal sperm, membrane depolarization by exposure to high KCl triggers Ca2+entry through CatSper only in alkaline conditions (pH 8.6) or afterin...

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PMID: 34650979
DOI: 10.3389/fcell.2021.733653

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