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Article

Structure of HCMV glycoprotein B in the postfusion conformation bound to a neutralizing human antibody

14 Sept 2015

Abstract excerpt

Human cytomegalovirus (HCMV) poses a significant threat to immunocompromised individuals and neonates infected in utero. Glycoprotein B (gB), the herpesvirus fusion protein, is a target for neutralizing antibodies and a vaccine candidate due to its indispensable role in infection. Here we show the crystal structure of the HCMV gB ectodomain bound to the Fab fragment of 1G2, a neutralizing human monoclonal...

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PMID: 26365435
DOI: 10.1038/ncomms9176

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