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Article

Effects of mutation, truncation, and temperature on the folding kinetics of a WW domain.

Journal of molecular biology - 20 Jul 2012

Maisuradze Gia G, Zhou Rui, Liwo Adam, Xiao Yi, Scheraga Harold A

Abstract excerpt

The purpose of this work is to show how mutation, truncation, and change of temperature can influence the folding kinetics of a protein. This is accomplished by principal component analysis of molecular-dynamics-generated folding trajectories of the triple β-strand WW domain from formin binding protein 28 (FBP28) (Protein Data Bank ID: 1E0L) and its full-size, and singly- and doubly-truncated mutants at...

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Identifiers

PMID: 22560992
DOI: 10.1016/j.jmb.2012.04.027
PMCID: PMC3586707

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