Article
Survival of human lymphoma cells requires B-cell receptor engagement by self-antigens.
Proceedings of the National Academy of Sciences of the United States of America - 3 Nov 2015
Young Ryan M, Wu Tianyi, Schmitz Roland, Dawood Moez, Xiao Wenming, Phelan James D, Xu Weihong, Menard Laurence, Meffre Eric, Chan Wing-Chung C, Jaffe Elaine S, Gascoyne Randy D, Campo Elías, Rosenwald Andreas, Ott German, Delabie Jan, Rimsza Lisa M, Staudt Louis M
Abstract excerpt
The activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) relies on chronic active B-cell receptor (BCR) signaling. BCR pathway inhibitors induce remissions in a subset of ABC DLBCL patients. BCR microclusters on the surface of ABC cells resemble those generated following antigen engagement of normal B cells. We speculated that binding of lymphoma BCRs to self-antigens initiates and...
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