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Article

Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia

9 Jun 2017

Abstract excerpt

Cell-autonomous B-cell receptor (BcR)-mediated signalling is a hallmark feature of the neoplastic B lymphocytes in chronic lymphocytic leukaemia (CLL). Here we elucidate the structural basis of autonomous activation of CLL B cells, showing that BcR immunoglobulins initiate intracellular signalling through homotypic interactions between epitopes that are specific for each subgroup of patients with homogeneous...

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PMID: 28598442
DOI: 10.1038/ncomms15746

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