Article
A disparate subset of double-negative T cells contributes to the outcome of murine fulminant viral hepatitis via effector molecule fibrinogen-like protein 2.
Immunologic research - 1 Apr 2016
Wu Di, Wang Hongwu, Yan Weiming, Chen Tao, Wang Ming, Han Meifang, Wu Zeguang, Wang Xiaojing, Ai Guo, Xi Dong, Shen Guanxin, Luo Xiaoping, Ning Qin
Abstract excerpt
The underlying immune-mediated mechanisms involved in virus-induced severe hepatitis have not been well elucidated. In this study, we investigated the role of CD3(+)CD4(-)CD8(-) double-negative T (DN T) cells in the pathogenesis of fulminant viral hepatitis (FVH) induced by murine hepatitis virus strain 3 (MHV-3). After MHV-3 infection, the proportions of DN T cells increased significantly in BALB/cJ mice, and...
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