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Article

Effector memory CD8 T cell response elicits Hepatitis E Virus genotype 3 pathogenesis in the elderly.

PLoS pathogens - 1 Feb 2021

El Costa Hicham, Gouilly Jordi, Abravanel Florence, Bahraoui Elmostafa, Peron Jean-Marie, Kamar Nassim, Jabrane-Ferrat Nabila, Izopet Jacques

Abstract excerpt

Genotype 3 Hepatitis E virus (HEV-3) is an emerging threat for aging population. More than one third of older infected patients develops clinical symptoms with severe liver damage, while others remain asymptomatic. The origin of this discrepancy is still elusive although HEV-3 pathogenesis appears to be immune-mediated. Therefore, we investigated the role of CD8 T cells in the outcome of the infection in...

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Identifiers

PMID: 33617602
DOI: 10.1371/journal.ppat.1009367
PMCID: PMC7932504

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